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Year:
2000
| Volume: 8
| Issue: 1
| Pages: 11-14
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Actual Problem |
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PEPTIDE NUCLEIC ACID (PNA) - MORE THAN ANYONE COULD IMAGINE AT THE FIRST SIGHT
Dimitar JAKIMOV, Dragana CETOJEVIC-SIMIN, Vesna KOJIC, Jasminka MRDJANOVIC |
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DOI:
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Abstract: |
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Peptide nucleic acid (PNA) is a nucleic acid analog and a fully synthetic DNA/RNA-recognizing ligand with a neutral peptide-like backbone. PNAs have several characteristics required for a good antisense/anti-gene oligonukleotide molecule. The extraordinary properties of PNA may potentiate the incoming entirely new era of routine diagnostic tests and analysis, including broad spectrum of clinical assays and environmental tests that will utilize the PNA technology. PNA will also perform a great impact on areas of in situ hybridization, cytogenetics and industrial microbiology. In this paper we present some recent achievements on peptide nucleic acids and discuss, from the viewpoint of literature, what the potential is and what the limitations of such compounds are. We also try to realize what possible applications in the field of oncology are, what the restrictions to use them are, and how PNA can influence the existing diagnostic methods and, hence, our present knowledge. |
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Key words:
Peptide nucleic acid (PNA); Antisense; Anti-gene oligonucleotides; Cellular delivery; Diagnostics |
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