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Year:
1997
| Volume: 5
| Issue: 1
| Pages: 15-16
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Original Article |
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CARDIOTOXICITY OF EPIRUBICIN IN STANDARD AND HIGH DOSES
Julian RAYNOV, Dobromir GOCHEV, Plamen PETROVSKI, Georgy GEORGIEV |
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DOI:
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Abstract: |
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The cardiotoxicity of Epirubicin (Farmorubicin - Pharmacia/Up John) in standard and high doses is discussed. Chemotherapy schedules: ABVD, ABCD, FEC, PE-6 coures and high doses Epirubicin (EPI) were applied in 64 patients (54 males and 10 famales) aged 19-64 years. We used the following criteria for assessment: ECG, LVEF, enzymes (ASAT, ALAT, CP). The results show no significant differences in both groups. Epirubicin can be applied successfully up to the cummulative dose of 1000 mg/m2 without any cardiotoxicity, as careful monitoring of the myocardial function shows. |
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Key words:
Epirubicin; Dosage; Adverse effects; Cardiotoxicity |
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