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Year:
2001
| Volume: 9
| Issue: 3
| Pages: 155-159
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Original Article |
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THE EFFECT OF NUCLEOSIDE ANALOGUES ON BIOCHEMICAL PARAMETERS IN RATS’ SERA
Ljiljana ANDRIJEVIC, Ilija ANDRIJEVIC |
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DOI:
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Abstract: |
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Background: Nucleoside analogues are new chemotherapeutic agents which showed activity against various cancer cells in vitro and in vivo. They modulate signal transduction pathways causing growth inhibition, differentiation, apoptosis and modu- lation of gene expression through distinct mechanisms of action. Tiazofurin is a synthetic analogue of purine nucleosides with modification on C6 atom, while 8-Cl-cAMP belongs to C8 analogue group. In our study, we examined the effect of two nucleoside analogues, tiazofurin and 8-Cl-cAMP, on biochemical parameters in rats' sera.
Methods: The experiments were carried out on adult Wistar rats. Tiazofurin and 8-Cl-cAMP were administered IP at a single dose (50 mg/kg/day) and four hours later the rats were sacrificed. In the sera of untreated and treated rats the following parameters were determined: urea, creatinine, uric acid, glucose, cholesterol, triglycerides, albumin, aspartate aminotransferase, alanine aminotransferase, creatine kinase, lactate dehydrogenase, gama-glutamyltransferase, alkaline phosphatase, alfa-amilase, calcium, phosphate and iron.
Results: The results showed that there were no significant statistical differences among biochemical parameters in the sera of treated animals in comparison to untreated rats.
Conclusion: These findings implicate that tiazofurin and 8-Cl-cAMP did not express toxic effects as measured by parameters above. |
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Key words:
Antineoplastic Agents; Purine Nucleoside+analogs and derivates; Cyclic AMP; Blood Chemical Analysis; Rats, Wistar |
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