Founded in 1993
  Year: 2003 | Volume: 11 | Issue: 1 | Pages: 5-8
  Original Article
  IMMUNOHISTOCHEMICAL EXPRESSION OF CD44 IN THYROID GLAND LESIONS
Anastasia KIZIRIDOU, Agni PANTIDOU, Chariclea DESTOUNI, Theano TOLIOU
  DOI:
  Abstract:
  Background: CD44 is a polymorphic family of cell surface proteoglycans and glycoproteins implicated in cell-to-cell and cell-to-matrix adhesion interactions and tumor metastasis. Its expression appears to be an indicator of invasive and metastatic behavior in carcinomas. The purpose of our study is to investigate the immunohistochemical expression of CD44 protein in thyroid lesions and its association to other histopathological parameters.
Methods: Samples from thyroid lesions were obtained from 40 patients treated in our hospital. The material consisted of 5 cases of multinodular goiter, 7 cases of thyroiditis (Hashimoto type), 5 cases of follicular adenoma, 4 cases of Hurthle cell tumor, 15 cases of thyroid carcinoma (11 papillary carcinomas, and 4 myeloid tumors), and 4 cases of normal thyroid tissue. Immunostaining was performed using the Ventana ES automated immunostainer. A monoclonal antibody was used and avidin-biotin method was applied to paraffin-embedded samples. A membranous immunostaining pattern was considered positive.
Results: CD44 expression was detected in three adenomas (60%), mostly of follicular type, and in eight carcinomas (72%). The CD44 immunostaining was especially apparent in papillary type of carcinomas, which showed high expression. In normal thy- roid tissue, a reduced CD44 expression was observed.
Conclusion: The results of our study indicate that deregulated expression of CD44 contributes to the ability of thyroid carcinomas for invasion and metastasis and may constitute a prognostic factor for malignant biological behavior.
  Key words: Antigens, CD44, Immunohistochemistry, Thyroid Diseases
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520