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Year:
2003
| Volume: 11
| Issue: 3
| Pages: 135-138
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Review Article |
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LOCALLY ADVANCED BREAST CANCER AS A MODEL FOR BIOMARKERS RESEARCH
Dragica NIKOLIC-VUKOSAVLJEVIC |
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DOI:
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Abstract: |
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The presence of the tumor in locally advanced breast cancer as an in vivo model offers the possibility of studying the effect of primary anticancer therapy on biological parameters. The hypothesis is that changes in certain molecular biomarkers, particular determinants of tumor growth such as proliferation or apoptosis, or molecular biomarkers of angiogenesis modulation, may predict clinical outcome. In this review, numerous molecular biomarkers of proliferation (ER a and ER b, PR, EGF-R family) and apoptosis (p53, Bcl-2 family), as well as molecular biomarkers of angiogenesis (FGF, VEGF) are discussed for their possible role in locally advanced breast cancer growth. |
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Key words:
Breast Neoplasms; Tumor Markers, Biological; Neoadjuvant Therapy |
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