| |
Year:
2007
| Volume: 15
| Issue: 3-4
| Pages: 65-68
|
| |
Article |
| |
ALPHA-TOCOPHERYL SUCCINATE (a-TOS) INFLUENCES CELL VITALITY AND ENZYME ACTIVITY IN EHRLICH ASCITES CARCINOMA CELLS
Stankov K, Bajin-Katic K, Stanimirov B, Karadžic D, Kovacevic Z. |
| |
DOI:
10.2298/AOO0704065S |
| |
Abstract: |
| |
Background: One of the most important strategies in research and development of new anticancer agents is the tumor-specific induction of apoptosis. The effects of semisynthetic derivative of vitamin E, (alpha-TOS, D-alpha-tocopheryl succinate), appear to be largely restricted to malignant cells.
Methods: We investigated the in vivo effects of intraperitoneall administered alpha-TOS on vitality of Ehrlich ascites carcinoma cells (EAC) in mice, as well as the influence of alpha-TOS on specific activity of enzymes involved in antioxidative mechanisms in EAC cells.
Results: According to our results, the intraperitoneal application of alpha-TOS induces the decrease of the EAC vitality, and the statistically significant alteration of the glutathione-dependent enzyme activity in EAC cells.
Conclusion: We may conclude that alpha-TOS is an important micronutrient, with significant impact on vitality and metabolism of malignant cells. |
| |
Key words:
Carcinoma, Ehrlich Tumor; Vitamin E; Oxidative Stress; Enzymes; Mice |
| |
Read
full text in PDF [Full
Text] |
|
|