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Year:
2017
| Volume: 23
| Issue: 2
| Pages: 20-24
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Article |
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EVALUATION OF CLINICAL, MORPHOLOGICAL AND PATHOHISTOLOGICAL CHARACTERISTICS OF THYMOMAS – OUR TEN YEAR EXPERIENCE
Aleksandra Lovrenski, Dragana Tegeltija, Ivana Jelicic, Milorad Bijelovic, Dejan ?uric Milana Panjkovic |
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DOI:
https://doi.org/10.2298/AOO1702020L |
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Abstract: |
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Background: Thymomas are rare neoplasms arising from tissue elements of the thymus. The objective of the study
was to analyse clinical characteristics of patients with thymoma, as well as morphological and patohistological
features of neoplasms. Methods: Retrospectively we studied 41 medical records and patohistological material of
patients reffered to the Institute for pulmonary diseases of Vojvodina between the January 2005 and December 2014.
Results: Patient age at presentation ranged from 19 to 77 years. A slight female preponderance was detected, with
24 (58.5%) females and 17 (41.5%) males being affected. All types of thymoma more often occured in males, accept
subtype B1. Patients with type A thymoma and subtype B1 were mainly asymptomatic, while patients with subtype
B2 and type AB presented with dyspnea, dysphagia, pain and cough. Myasthenia gravis often was associated with
type A (40%). The most common histologic type was subtype B1. Twenty three (56%) patients had a tumor diameter
between 5 and 10 cm. Five patients had malignant thymoma, and the most common types of thymoma that showed
signs of capsula invasion or pleural and pericardial implants were type AB (60%) and subtype B2 (50%). Biopsies
of suspected tissue were obtained through a sternotomy, video-assisted thoracoscopy surgery, and video-assisted
mini thoracotomy, and after setting a diagnosis on ex tempore analysis, the lesions were removed by thymectomy or
extirpation of the tumor mass. Conclusion: Thymomas have variable clinical presentations. Clinical outcome correlates
with histological type, size and clinical stage, as well as the ability to achieve complete tumor resection. |
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Key words:
Thymoma, Neoplasms |
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