Founded in 1993
  Year: 1997 | Volume: 5 | Issue: 1 | Pages: 15-16
  Original Article
  CARDIOTOXICITY OF EPIRUBICIN IN STANDARD AND HIGH DOSES
Julian RAYNOV, Dobromir GOCHEV, Plamen PETROVSKI, Georgy GEORGIEV
  DOI:
  Abstract:
  The cardiotoxicity of Epirubicin (Farmorubicin - Pharmacia/Up John) in standard and high doses is discussed. Chemotherapy schedules: ABVD, ABCD, FEC, PE-6 coures and high doses Epirubicin (EPI) were applied in 64 patients (54 males and 10 famales) aged 19-64 years. We used the following criteria for assessment: ECG, LVEF, enzymes (ASAT, ALAT, CP). The results show no significant differences in both groups. Epirubicin can be applied successfully up to the cummulative dose of 1000 mg/m2 without any cardiotoxicity, as careful monitoring of the myocardial function shows.
  Key words: Epirubicin; Dosage; Adverse effects; Cardiotoxicity
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520