Founded in 1993
  Year: 1997 | Volume: 5 | Issue: 2 | Pages: 53-55
  Original Article
  IMMUNOHISTOCHEMICAL STUDY OF EXPRESSION OF HEAT-SHOCK PROTEIN 27 (HSP27) IN NORMAL AND MALIGNANT ENDOMETRIUM
Omer DEVAJA, Roger BJ KING, Nawal W DERIAS, Andreas PAPADOPOULOS, Shanti KANKIPATI RAJU
  DOI:
  Abstract:
  Background: Some members of Heat-Shock Protein (HSP) family have known be involved in steroid action as components of the steroid receptor complex. A 27 kDa protein(HSP277) synonymous with p24 and p29 has also been implicated in oestrogen action either as an oestrogen regulated protein or as a protein that will react with activated but not native ER. This paper details the changes seen in normal endometrial epithelial and stromal cells through out the menstrual cycle and different grades of malignant endometrium.
Methods: Indirect method of immunohistochemical staining was performed using D5 antibody in histological sections of endometrial tissue obtained from 80 women (50 benign and 30 malignant endometrium).
Results: Staining was always cytoplasmic in normal and malignant endometrium. Different expression of HSP27 was evident depending on stage of the menstrual cycle and tumour grade. There was clear relationship between histological grade of tumour and HSP27 expression. A linear trend analysis of the expression of the HSP27 in tumour is statistically significant (p=0.003).
Conclusion: The findings in this study suggest that HSP27 is related tooestrogen regulation in the benign endometrium although these regulatory mechanisms in glandular and stromal cells may be different. HSP27 may be an excellent marker of tumour differentiation in endometrial canaer however in this study we are unable to asses the relationship of expression of HSP27 to overall or disease free survival as the follow up of these patient was less than 2 years.
  Key words: HSP27; Expression; Endometrium; Tumour differentiation
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520