Founded in 1993
  Year: 1997 | Volume: 5 | Issue: 2 | Pages: 75-77
  Review Article
  MONOCLONAL GAMMAPATHIES - ARE THEY ALL MALIGNANCIES OR PREMALIGNANCIES?
Jiri RADL
  DOI:
  Abstract:
  This short review of own work questions the wide spread clinical dogma that monoclonal gammapathies (MG) usually reflect a B cell malignancy or at least a pre-malignancy. Research on B-cell proliferative disorders in an animal model - the aging C57BL/KaLwRij mouse - revealed that there are at least four major mechanisms in the development of MG. Many of the findings were confirmed in subsequent clinical studies and lead to a new classification of MG according to their biology and possible pathogenesis. Most of MG can be classified into one of the following 4 categories: 1.B-cell malignancies, 2.B-cell benign neoplasia, 3. MG due to an immunodeficiency with T/B cell imbalance, and 4. Antigen driven MG. The B-cell malignancies, i.e. MG of the first category, represent only 1% of all MG detected by routine laboratories. However, there are no reliable tests available yet for the differential diagnosis among the 4 categories of MG in the clinical praxis.
  Key words: Monoclonal gammapathies-pathogenesis; Monoclonal gammapathies-four categories; B cell proliferative disorders
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520