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Year:
1999
| Volume: 7
| Issue: 2
| Pages: 43-48
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Original Article |
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HPV TYPING IN CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS (SIL) - OUR EXPERIENCE AFTER 1000 STUDIED PATIENTS
Branko STANIMIROVIC, Nada KULJIC-KAPULICA, Nikola ANTIC, Violeta STANIMIROVIC, Mladenko VASILJEVIC, Jelena POPOVIC-LAZIC |
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DOI:
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Abstract: |
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Background: Existence of an entrance site on the portio vaginalis uteri (PVU) and contact with sexually transmitted human papillomaviruses (HPV) are two essential conditions for the occurrence of cervical squamous intraepithelial lesions (SIL).
Methods: In the period October 1994 - August 1998 we studied 1000 female patients with cervical SIL for the presence of HPV in the above lesions. SIL were detected by means of colposcopy, cytodiagnostic methods and by histological examination of biopsy specimens, while HPV typing was perfomed employing in situ hybridization method.
Results: 793 (79.3%) of subjects had lesions of low histologz grade (LSIL), ehile 207 (20.7%) presented with high histology grade lesions (HSIL). Presence of HPV infection was detected in 66% of the studied patients, with the lesions of LSIL type being significantly more often HPV negative or HPV 6/11 positive, as compared to those of HSIL type, where oncogenic HPV types (16,18,31,33) were significantly more common. The presence of oncogenic types of viruses in the lesions was, apart from histological assessment of the lesion severity, one of major criteria for deciding on the necessity and the type of treatment to be instituted. This was particularly significant in LSIL, since HSIL require oxidation regardless of their HPV status. Analysis of colposcopic findings showed that cervical SIL were most commonly manifested as a mosaic, while cytodiagnostic methods have not proven sufficiently sensitive in detecting the above changes, especially where LSIL type was present. Among the studied risk factors for occurrence of the above diseases and in defining the risk groups of women, of significance were the risk factors related to the sexual behavior.
Conclusion: In addition to colposcopy, cytodiagnostics and histopathology, HPV typing has become the fourth basic method in the detection and treatment of cervical SIL. |
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Key words:
Cervical squamous intraepithelial lesions; Human papillomaviruses; Cervical neoplasia; Risk factor for SIL occurrence Multiple superficial basocellular carcinomas; Basocellular naevus syndrome |
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