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Year:
2000
| Volume: 8
| Issue: 2
| Pages: 47-50
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Original Article |
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FRACTAL DIMENSION OF HEPATOCYTES` NUCLEI IN NORMAL LIVER VS HEPATOCELLULAR CARCINOMA (HCC) IN HUMAN SUBJECTS - PRELIMINARY RESULTS
Aleksandar S. KERENJI, Zoran L. BOZOVIC, Milos M. TASIC, Zoran M. BUDIMLIJA, Istvan A. KLEM, Agneza F. POLZOVIC |
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DOI:
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Abstract: |
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Background: With the aim of determining the fractal dimension, as an expression of quantitative measure of nuclear shape, in normal and malignant hepatocytes, the box-counting method was performed, followed by linear approximation of necessary numeric values by first degree polynoma. Materials and Methods: A total of 308 human hepatocyte's nuclei on digitized microscopic images of histological sections (119 normal and 189 hepatocellular carcinoma nuclei) were submitted to fractal analysis, using haematoxylin-eosin stained liver biopsy specimen. Results: The obtained mean fractal dimension for nuclei of normal hepatocytes was 1.0521±0.16 versus nuclei of malignant hepatocytes, where was 1.15299±0.126. Conclusion: The average values of the nuclear fractal dimensions presented, among normal and malignant hepatocytes are statistically significantly different(p<0.0039). |
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Key words:
Hepatocellular carcinoma; Nucleus; Fractal analysis; Mathematical model; Humans |
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