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Year:
2001
| Volume: 9
| Issue: 1
| Pages: 27-28
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Actual Problem |
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MAGNETIC RESONANCE IMAGING AND MAGNETIC RESONANCE ANGIOGRAPHY IN CENTRAL NERVOUS SYSTEM SYSTEMIC LUPUS ERYTHEMATOSUS
Ivana VUKADINOVIC, Dusan KOZIC, Milos LUCIC, Jelena OSTOJIC, Mladen PRVULOVIC |
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DOI:
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Abstract: |
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The aim of the study was to evaluate MRI and MRA in CNS involvement of systemic lupus erythematosus (SLE). It was a retrospective study of 19 patients who were of 20-40 years of age and (17 F and 2 M) with clinical signs similar to migraine, with epilepsy or psychoses and with positive screening test for SLE. Antinuclear antibodies (ANA), anti-DNA antibodies, antiphospholipid antibodies were examined on MR imager Siemens Magnetom SP 63-4000 (1.5 T). Multiple small foci in subcortical and deep hemispheric white matter were revealed in 79.6% of patients. In 52.6% of patients we found large zones of cortical and subcortical edema. The combination of cortical and subcortical involvement was found in one third of patients. Inflammation and necrosis of the cerebral arteries may occur as a result of immuno-related processes. The MR angiographic results revealed several segments of reduced signal intensity in 63% of patients. MRI and MRA promised to be a unique and powerful tool for the clinical investigation of CNS involvement in SLE. |
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Key words:
Lupus Erythematosus, Systemic; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Central Nervous System Diseases |
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