Founded in 1993
  Year: 2001 | Volume: 9 | Issue: 3 | Pages: 171-174
  Review Article
  PLEIOTROPIC EFFECT OF GENISTEIN MAKES IT A PROMISING CANCER PROTECTIVE COMPOUND
Ana NEDELJKOVIC, Sinisa RADULOVIC, Snezana BJELOGRLIC
  DOI:
  Abstract:
  Of all environmental factors known to influence cancer, diet appears to be one of the most significant. Worldwide geographical variation in cancer incidence has shown a relation with differences in the dietary habits of populations at high and low cancer risk. The interest in soy products has begun when scientists rose the question why the inci- dence of breast, colorectal and prostate cancer is much higher in the Western world compared to the countries in Asia. One of the reasons for much lower mortality rate from cancer in Asia than in America for example, they found in commonly consumption soy-foods in the Oriental civilizations. Genistein, main isoflavone in soy, interferes with many biochemical pathways and its mode of action in the live cell is complex and multidirectional. Genistein was shown to be a specific and potent inhibitor of PTK activity, as well as an inducer of cancer cell differentiation mainly through the inhibition of inositol phospholipid metabolism. This isoflavone, as a weak phytoestrogen, may exerts both estrogenic and antiestrogenic effects on metabolism, depending on many factors, including its concentration, the concentration of endogenous estrogens, and individual characteristics such as sex and menopausal status. Genistein antagonizes tumor cell growth through both cell cycle arrest and induction of apoptosis. By stabi- lizing DNA topo II to DNA, genistein produces dynamic changes in the chromatin structure and alternations in gene expression that favor the differentiated phenotype. Genistein was able to inhibit in vitro angiogenesis. All mentioned properties and its extremely low toxicity make genistein a strong candidate in cancer prevention, and probably one day even in cancer treatment.
  Key words: Genistein; Isoflavones; Neoplasms+prevention and control
  Read full text in PDF [Full Text]
Next article

Previous article

Table of contents

Browse all Volumes

Search all Volumes
By keywords
By authors

  Search AoO for:
 

  Related articles in AoO:
 
About Journal | Editorial Board | Editorial Policy | Instructions for Authors | Open Access | Advertising | Payed issues | Article Submission Charge | Contact
Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520