Founded in 1993
  Year: 2001 | Volume: 9 | Issue: 3 | Pages: 193-194
  Short Report
  THE COMPARATIVE MUTAGENIC ACTION OF 7,12-DIMETHYLBENZ(A)ANTHRACENE IN THE ARMENIAN HAMSTERS AND MICE
Armen K. NERSESYAN, Victor A. KOUMKOUMADJIAN
  DOI:
  Abstract:
  The comparative mutagenic action of 7,12-dimethylbenz(a)anthracene (DMBA) on mice and the Armenian hamsters (AH) was studied by means of micronucleus (MN) test in bone marrow polychromatic erythrocytes. It was shown that MN level in bone marrow cells of the AHs caused by DMBA was significantly lower than in mice although the carcinogen was used at equitoxic doses. Our data show that the AHs are much more resistant to mutagenic action of DMBA than mice. This may be due to the unique resistance of the AHs to the toxic action of chemical agents.
  Key words: Micronucleus tests; 7,12-Dimethylbenz(a)anthracene; Cricetulus; Rats; Mice
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520