Founded in 1993
  Year: 2003 | Volume: 11 | Issue: 2 | Pages: 81-89
  Review Article
Karmen STANKOV, Giovanni ROMEO
  Oxyphilic tumors of the thyroid gland are rare tumors characterized by the presence of Hurthle cells - mitochondrion-rich, eosinophilic epithelial cells. Hurthle cell carcinomas (HCC) of the thyroid behave in a more aggressive fashion as compared to other well-differentiated thyroid cancers. Many recent studies have been focused on the further elucidation of pathogenesis and the role of mitochondrial hyperplasia in carcinogenesis of these neoplasms. The importance of combining morphological and genetic approaches in the study of HCC has been emphasized by the difficulties encountered in establishing adequate differential diagnostic criteria between benign and malignant forms, as well as by the resistance of HCC to radio and chemotherapy. It has been well documented that the Hurthle cells are characterized by profound aberrations in the nuclear and mitochondrial genome and by alterations in oncogenes, tumor suppressor genes and other key genes involved in energy metabolism, proliferation and apoptosis.
  Key words: Adenocarcinoma; Thyroid Neoplasms; Adenoma, Oxyphilic; Chromosomes; Genetics; Mitochondria; Apoptosis
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Founder and owner: Oncology Institute of Vojvodina, Serbia
Publisher: Oncology Institute of Vojvodina
Co-publisher: Faculty of Medicine, University of Novi Sad
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520