Founded in 1993
  Year: 2003 | Volume: 11 | Issue: 3 | Pages: 135-138
  Review Article
  LOCALLY ADVANCED BREAST CANCER AS A MODEL FOR BIOMARKERS RESEARCH
Dragica NIKOLIC-VUKOSAVLJEVIC
  DOI:
  Abstract:
  The presence of the tumor in locally advanced breast cancer as an in vivo model offers the possibility of studying the effect of primary anticancer therapy on biological parameters. The hypothesis is that changes in certain molecular biomarkers, particular determinants of tumor growth such as proliferation or apoptosis, or molecular biomarkers of angiogenesis modulation, may predict clinical outcome. In this review, numerous molecular biomarkers of proliferation (ER a and ER b, PR, EGF-R family) and apoptosis (p53, Bcl-2 family), as well as molecular biomarkers of angiogenesis (FGF, VEGF) are discussed for their possible role in locally advanced breast cancer growth.
  Key words: Breast Neoplasms; Tumor Markers, Biological; Neoadjuvant Therapy
  Read full text in PDF [Full Text]
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520