Founded in 1993
  Year: 2003 | Volume: 11 | Issue: 3 | Pages: 165-167
  Review Article
  CHEMOTHERAPY OPTIONS FOR METASTATIC COLORECTAL CARCINOMA; FIRST, SECOND, THIRD LINE...
Zorica TOMASEVIC, Svetislav JELIC, Davorin RADOSAVLJEVIC, Ivan POPOV
  DOI:
  Abstract:
  For almost 40 years, the only option for patients with unresectable metastases was treatment with 5-fluorouracil. In the last decade, new drugs became available that changed attitude toward treatment of metastatic CRC, as well as the prognosis for some patients although the "story" of 5-FU is not finished yet. Irinotecan, oxaliplatin and oral fluoropyrimidines produces higher response rates, longer symptom control and longer survival for the majority of the patients with unresectable metastases. Neoadjuvant chemotherapy is particularly interesting, because according to the results of some studies, it actually allows curative resections of previously unresectable liver metastases. This paper deals with the current status of chemotherapy of metastatic CRC, and some dilemmas about that issue. Also, we report results of third line chemotherapy of metastatic CRC patients treated at the Institute for Oncology and radiology of Serbia (IORS).
  Key words: Colorectal Neoplasms; Neoplasm Metastasis; Antineoplastic Combined Chemotherapy Protocols
  Read full text in PDF [Full Text]
Next article

Previous article

Table of contents

Browse all Volumes

Search all Volumes
By keywords
By authors

  Search AoO for:
 

  Related articles in AoO:
 
About Journal | Editorial Board | Editorial Policy | Instructions for Authors | Open Access | Advertising | Payed issues | Article Submission Charge | Contact
Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520