Founded in 1993
  Year: 2004 | Volume: 12 | Issue: 1 | Pages: 35-38
  Original Article
  CHANGES OF BIOCHEMICAL PARAMETERS IN RAT INTESTINAL MUCOSA INDUCED BY METHOTREXATE AND EFFECTS OF ENTERAL ADMINISTRATION OF GLUTAMINE
Katica BAJIN-KATIC, Karmen STANKOV, Zoran KOVACEVIC
  DOI:
  Abstract:
  Background: Rapidly proliferating crypt cells of the intestinal epithelium, the precursors of the mature enterocytes, are extremely sensitive to the effects of cytostatic agents. We investigated the effects of the methotrexate on rat intestinal mucosa in order to get the information on biochemical indicators of intestinal damage.
Methods: Biochemical parameters were investigated in isolated intestinal mucosa of Sprague-Dawley rats, previously treated with methotrexate by intraperitoneal administration. Glutamine was dissolved in water and administered orally.
Results: The activity of glutaminase and alkaline phosphatase showed the enzymatic response to different doses of methotrexate. The activity of both enzymes was significantly lower in the mucosa of treated animals, compared to control group.
Conclusion: Minimal mucosal damage and regeneration time is dose dependent and influenced by the dosage schedule of antitumor therapy.
  Key words: Methotrexate; Glutamine; Intestinal Mucosa; Rats; Drug Toxicity
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520