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Year:
2006
| Volume: 14
| Issue: 1-2
| Pages: 30-34
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Review Article |
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CLONING OF THE GENES FOR NON-MEDULLARY THYROID CANCER: METHODS AND ADVANCES
Stankov K, Romeo G. |
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DOI:
10.2298/AOO0602030S |
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Abstract: |
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In last ten years, significant advances have occurred in thyroid endocrinology, as a consequence of the generalized use of molecular biology techniques. New genes involved in the development of thyroid cancer have been identified, which had a great impact on our understanding of thyroid cancer predisposition. All cancers are genetic in origin because they arise from mutations in a single somatic cell, but the genetic changes in sporadic cancers are confined to a particular tissue. In inherited cancers, a predisposing mutation is present in all somatic cells and in the germ line, which enables the transmission of risk to the next generation. Cancer genetics offers a model of how information on the genetics of inherited cancers could affect identification of individuals at increased genetic risk. |
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Key words:
Thyroid Neoplasms; Cloning, Molecular; Oncogenes; Genes, Tumor Supressor; Genetic Predisposition to Disease |
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