Founded in 1993
  Year: 2006 | Volume: 14 | Issue: 1-2 | Pages: 30-34
  Review Article
  CLONING OF THE GENES FOR NON-MEDULLARY THYROID CANCER: METHODS AND ADVANCES
Stankov K, Romeo G.
  DOI: 10.2298/AOO0602030S
  Abstract:
  In last ten years, significant advances have occurred in thyroid endocrinology, as a consequence of the generalized use of molecular biology techniques. New genes involved in the development of thyroid cancer have been identified, which had a great impact on our understanding of thyroid cancer predisposition. All cancers are genetic in origin because they arise from mutations in a single somatic cell, but the genetic changes in sporadic cancers are confined to a particular tissue. In inherited cancers, a predisposing mutation is present in all somatic cells and in the germ line, which enables the transmission of risk to the next generation. Cancer genetics offers a model of how information on the genetics of inherited cancers could affect identification of individuals at increased genetic risk.
  Key words: Thyroid Neoplasms; Cloning, Molecular; Oncogenes; Genes, Tumor Supressor; Genetic Predisposition to Disease
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520