Founded in 1993
  Year: 2007 | Volume: 15 | Issue: 1-2 | Pages: 15-18
  Article
  HER-2/neu OVEREXPRESSION IN INVASIVE DUCTAL BREAST CANCER – AN ASSOCIATION WITH OTHER PROGNOSTIC AND PREDICTIVE FACTORS
Ivkovic-Kapicl T, Kneževic-Ušaj S, Panjkovic M, Đilas-Ivanovic D, Golubovic M.
  DOI: 10.2298/AOO0702015I
  Abstract:
  Background: HER-2/neu is a proto-oncogene that is amplified/overexpressed in 15 to 30% of invasive breast cancers. The purpose of this study was to determine if any relationship exist between HER-2/neu protein overexpression and estrogen receptor (ER), progesterone receptor (PR), grade, size, and lymph node status in female breast cancer.
Methods: A total of 100 cases of invasive ductal breast cancer were included in this study. The hormone receptors and HER-2/neu were studied immunohistochemically (IHC). Using the HER-2/neu DAKO scoring system, scores of 0, 1+ and 2+ were defined as negative and 3+ as positive.
Results: HER-2/neu protein overexpression was seen in 20 (20%) of cases. HER-2/neu protein overexpression was present in 4 of 52 T1 lesions (8%), in 11 of 37 T2 lesions (30%), in 3 of 6 T3 lesions (50%), and in 2 of 5 T4 lesions (40%), (p<0.05). Protein overexpression was seen in 7 of 17 grade III tumors (41%), and 13 of 61 grade II tumors (21%). Overexpression was not detected in grade I tumors (p<0.01). Of the 20 Her-2/neu positive cases, ER- and PR-negative status was detected in 60% and 70%, respectively.
Conclusion: Statistically significant correlation was found between HER-2/neu protein overexpression and large tumor size, high histological grade, and ER-, PR-negativity. There was no correlation with lymphonodal status.
  Key words: Breast Neoplasms; Carcinoma, Ductal, Breast; Receptor, erbB-2; Neoplasm Invasiveness; Immunohistochemistry; Proto-Oncogene Proteins; Gene Expression Regulation, Neoplastic
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520