Founded in 1993
  Year: 2007 | Volume: 15 | Issue: 1-2 | Pages: 19-23
  Article
  LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER - PRETREATMENT PROGNOSTIC FACTORS: DISEASE STAGE, TUMOR HISTOPATHOLOGICAL CHARACTERISTICS, THE PATIENT-RELATED FACTORS
Vasic Lj.
  DOI: 10.2298/AOO0702019V
  Abstract:
  Background: The existing tumor-node-metastasis staging system ignores numerous clinical, therapeutic, and biological characteristics of lung cancer and psychomotor condition of a patient because it is based on the anatomic extent of disease. Therefore, there is a possibility of inadequate choice of therapy for any individual patient. Based on the disease stage, histopathological characteristics of the tumor and the patient-related factors (sex, age, Karnofsky status, accompanying diseases) the outcome of the disease can be predicted in patients with inoperable and unresectable non-small lung cancer.
Methods: This report is a prospective clinical study that included patients with histopathological verified non-small cell lung cancer, followed up for a six-month period, from the beginning of the treatment. The following data were recorded: sex, age, histological cancer type, stage, Karnofsky status, and comorbid diseases.
Results: The study showed planocellular carcinoma was more dominant among men than among women and that and at the diagnosis, most patients were in IIIb or IV stage. There was a decrease in psychomotor status of patients. The length of survival depended on Karnofsky index (p= 0.000), comorbidities – chronic myocardiopathy (p= 0.001), diabetes mellitus type 2 (p =0.007), myocardial infraction (p= 0.005), and the stage of the disease (p= 0.001).
Conclusion: Psychomotor status of a patient, comborid diseases, and the stage of disease are the factors that determine patient’s tolerance to oncology treatment.
  Key words: Carcinoma, Non-Small-Cell Lung; Neoplasm Staging; Prognosis; Karnofsky Performance Status; Comorbidity; Age Factors; Sex Factor; Psychomotor Performance; Neoplasms by Histologic Type
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520