Founded in 1993
  Year: 2007 | Volume: 15 | Issue: 3-4 | Pages: 65-68
  Article
  ALPHA-TOCOPHERYL SUCCINATE (a-TOS) INFLUENCES CELL VITALITY AND ENZYME ACTIVITY IN EHRLICH ASCITES CARCINOMA CELLS
Stankov K, Bajin-Katic K, Stanimirov B, Karadžic D, Kovacevic Z.
  DOI: 10.2298/AOO0704065S
  Abstract:
  Background: One of the most important strategies in research and development of new anticancer agents is the tumor-specific induction of apoptosis. The effects of semisynthetic derivative of vitamin E, (alpha-TOS, D-alpha-tocopheryl succinate), appear to be largely restricted to malignant cells.
Methods: We investigated the in vivo effects of intraperitoneall administered alpha-TOS on vitality of Ehrlich ascites carcinoma cells (EAC) in mice, as well as the influence of alpha-TOS on specific activity of enzymes involved in antioxidative mechanisms in EAC cells.
Results: According to our results, the intraperitoneal application of alpha-TOS induces the decrease of the EAC vitality, and the statistically significant alteration of the glutathione-dependent enzyme activity in EAC cells.
Conclusion: We may conclude that alpha-TOS is an important micronutrient, with significant impact on vitality and metabolism of malignant cells.
  Key words: Carcinoma, Ehrlich Tumor; Vitamin E; Oxidative Stress; Enzymes; Mice
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520