Founded in 1993
  Year: 2010 | Volume: 18 | Issue: 3 | Pages: 60-64
  Article
  HEAD AND NECK CANCER IN YOUNG ADULTS TREATED WITH 3-D CONFORMAL RADIOTHERAPY
Igor Stojkovski, Valentina Krstevska, Nenad Mitreski, Eleonora Stojkovska, Daniela Simonova
  DOI: 10.2298/AOO1003060S
  Abstract:
  Background: Purpose of this study was to determine patterns of failure in young adults with head and neck cancer treated with 3-D conformal radiotherapy.
Methods: Twenty-eight patients with head and neck cancer younger than 41 years of age were treated with 3-D conformal radiotherapy. Patients' median age was 31.4 years. Radiotherapy was delivered in the median total dose of 67.2 Gy to PTV (range, 60.0-70.0 Gy) with or without concurrent cisplatin.
Results: The median duration of follow-up was 20 months. Distant metastases were the most frequent pattern of failure. The locoregional relapse-free survival (LRR-FS) rate at 2 years was 66.6%. The median duration of LRR-FS was 15 months. The distant metastases relapse-free survival (DMR-FS) rate at 2 years was 65.7%. The median duration of DMR-FS was also 15 months. The overall survival (OS) rate at 2 years was 57.2%. The median duration of OS wa 20 months.
Conclusion: Radiotherapy with or without concurrent chemotherapy plays an important role in treatment of patients with head and neck cancer. Recent developments of new radiotherapy techniques have increased rates of local control. Distant metastases remain the most frequent pattern of failure in this group of young adults with head and neck cancer. Introducing new cytotoxic and target therapies in future could lead to better outcome in this subgroup of patients.
  Key words: Head and Neck Neoplasms; Young Adults; Radiotherapy, Conformal
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520