Founded in 1993
  Year: 2012 | Volume: 20 | Issue: 1-2 | Pages: 8-11
  Article
  PALLIATIVE CHEMOTHERAPY FOLLOWED BY CONSOLIDATION RADIOTHERAPY IN PATIENTS WITH ADVANCED AND METASTATIC NON-SMALL CELL LUNG CANCER NOT SUITABLE FOR RADICAL TREATMENT
Hany Eldeeb, Philip Camileri, Choi Mak
  DOI: 10.2298/AOO1202008E
  Abstract:
  Background: This is a retrospective study to assess the effectiveness of consolidation radiotherapy (CRT) following palliative chemotherapy in patients with metastatic or locally advanced non-small cell lung cancer (NSCLC) who are not suitable for radical treatment.
Methods: This study involved retrospective analysis of a prospective database of Northampton Oncology Center from January 2005 through December 2010, 63 patients with advanced / metastatic NSCLC treated at the oncology center were enrolled. Patients were either treated with high dose (39/36 Gy /13-12 fractions, group 1) or low dose (20 Gy /5 fractions, group 2) CRT or there were those who were not offered any CRT (group 3).
Results: There was no significant difference between the three groups as regard age, sex, performance status, comorbidities or chemotherapy given. However, there was a statistically significant difference as regard the stage P = 0.009 with more stage IV patients at group II and III compared to group I. The mean survival for the three groups was 27m, 14m & 15m respectively.There was a statistically significant improvement of survival in patients treated with high dose palliative CRT compared to the other two groups (P = 0.006). In multivariate analysis only the radiotherapy dose remains as the only statistical significant factor affecting the survival with hazard ratio 0.372 and confidence interval (0.147-0.726).
Conclusion: Despite the limitation of our retrospective study, it is worth considering CRT approach for patients with advanced and metastatic NSCLC not suitable for radical treatment who have not progressed on chemotherapy.
  Key words: Carcinoma, Non-Small-Cell Lung; Radiotherapy; Radiotherapy Dosage; Antineoplastic Agents; Treatment Outcome
  Read full text in PDF [Full Text]
Next article

Previous article

Table of contents

Browse all Volumes

Search all Volumes
By keywords
By authors

  Search AoO for:
 

  Related articles in AoO:
 
About Journal | Editorial Board | Editorial Policy | Instructions for Authors | Open Access | Advertising | Payed issues | Article Submission Charge | Contact
Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520