Founded in 1993
  Year: 1997 | Volume: 5 | Issue: 3 | Pages: 147-149
  Original Article
  BIOLOGICAL ACTIVITY OF WATER-SOLUBLE FULLERENCE: C60(OH)24
Gordana BOGDANOVIC, Mirjana VOJINOVIC-MILORADOV, Vesna KOJIC, Aleksandar DJORDJEVIC, Janos CANADI, Djuro KORUGA, Vladimir Vit. BALTIC, Dunja TABS
  DOI:
  Abstract:
  Background: Fullerenes and their water-soluble derivatives have recently become a topic of interest in biomedicine. Here, we report on citotoxicity and antiproliferative activity of water-soluble derivative of fullerene C60 against five cell lines: K562, MCF7, Raji, L929 and BHK.
Methods: The cells were continuously treated with derivative up to 24 or 48 h and citotoxicity and cellular survival were assessed by MTS/PMS and dye exclusion test.
Results: Water-soluble fullerene derivative induce low growth-inhibition rate in cell lines except Raji, during 24 or 48 h. Growth-inhibition was transient and the cells, that had been previously treated with derivative in duration of 48 h, successfully survived; after 48 h of growth in fresh medium they achieved the control sample values, regardless the concentration of derivative and the type of cell line.
Conclusion: The preliminary results of this study showed that generally low but transient growth-inhibition activity of water-soluble derivative C60 was obtained on the most of cell lines, regardless of their source and features. Raji cells appeared to be resistant to growth-inhibition activity of derivative in given experimental conditions.
  Key words: Fullerene C60; Cell lines; Cytotoxicity; Cell growth; Tetrazolium salts; MTS/PMS assay
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520