Founded in 1993
  Year: 1997 | Volume: 5 | Issue: 4 | Pages: 195-196
  Original Article
  METHYLENE/CHOLINE INDEX AS A POSSIBLE PARAMETER OF CHOICE IN DISTINGUISHING CEREBRAL METASTASES FROM PRIMARY CNS TUMORS - PRELIMINARY RESULTS
Vera DIKLIC
  DOI:
  Abstract:
  Background: Methylene/choline ratio in the CNS tumor staging has not been investigated yet. In this study we investigated lipid shape and peak heights in order to see whether they vary from primary to secondary CNS tumors.
Methods: The composite methylene and methyl aliphatic peaks were analyzed by the localized 1H-MR spectroscopy in the area of 0.8 - 1.4 ppm in patients with primary CNS tumors, in those with CNS metastases and were compared with the large group of patients with different nonneoplastic neurological disturbances where elevated lipids in these frequency regions had been found.
Results: Preliminary results of this study suggests that the shape of methylene and methyl peaks in the range of 1.2 - 1.4 ppm and 0.8 - 0.9 ppm, respectively, as well as the methylene/choline index differ between primary and secondary CNS tumors.
Conclusion: Methylene/choline ratio could become the parameters of choice in distinguishing solitary CNS metastasis from primary brain tumor.
  Key words: CNS tumors; MR-spectroscopy; Differential diagnosis
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520