Founded in 1993
  Year: 1998 | Volume: 6 | Issue: 2 | Pages: 45-47
  Original Article
Jovan ANTOVIC,Milorad BAKIC,Zoran MILENKOVIC,Aleksandar IGIC,Miodrag VUCIC
  Background: Brain tissue is one of the richest sources of tissue factor in human organism and blood coagulation and fibrinolysis abnormalities after brain damage are common. This problem is widely described after head trauma, but there is less data about these abnormalities after brain tumor surgeries.
Methods: Blood coagulation and fibrinolysis in 30 patients with brain tumors (12 with gliomas, 12 with meningeomas, and 6 with brain metastases) were screened in the first 24 hours after surgery, using prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer, antithrombin III (ATIII), factor VII (FVII) and alpha-2 antiplasmin (alpha-2 AP).
Results: A significant decrease of PT, FVII, ATIII and alpha-2 AP, prolongation of aPTT and increase of D-dimer have been noticed. Statistically significant differences in estimated parameters after different brain tumors surgery have not been noticed.
Conclusion: Coagulation and fibrinolysis abnormalities in almost all patients point to the necessity of routine coagulation estimation in all patients in first 24 hours after brain surgery.
  Key words: Blood coagulation; Fibrinolysis; Brain tumors; Brain surgery
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520