Founded in 1993
  Year: 1998 | Volume: 6 | Issue: 3 | Pages: 109-113
  Review Article
  OXIDATIVE STRESS AND GLUTATHIONE - ASSOCIATED ANTIOXIDATIVE SYSTEMS IN MALIGNANT CELLS
Karmen STANKOV, Zoran KOVACEVIC
  DOI:
  Abstract:
  Free radical-mediated damage appears to be of primary significance in aging, cancer and many other pathological conditions. Reactive oxygen species are continually produced during the biochemical aerobic reactions, which occur as a part of a normal cell metabolism, or during the biotransformation of xenobiotics, including carcinogens as well as antitumor drugs. Numerous forms of cellular damage are due to oxidative stress induced by free radicals. Glutathione (GSH) is universal protectant against electrophilic challenge and it is essential in the detoxification of redox active drugs. Glutathione is also involved in biochemical mechanisms that can cause tumors to become resistant to anticancer drugs. The importance of glutathione and associated enzymes in antioxidative defense of malignant cells lies in the provision of an enhanced rate and extent of detoxification, helping to maintain the amount of damage below that which may trigger apoptosis.
  Key words: OXIDATIVE STRESS; GLUTATHIONE; CELLS NEOPLASMS; APOPTOSIS
  Read full text in PDF [Full Text]
Next article

Previous article

Table of contents

Browse all Volumes

Search all Volumes
By keywords
By authors

  Search AoO for:
 

  Related articles in AoO:
 
About Journal | Editorial Board | Editorial Policy | Instructions for Authors | Open Access | Advertising | Payed issues | Article Submission Charge | Contact
Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520