Founded in 1993
  Year: 1998 | Volume: 6 | Issue: 3 | Pages: 135-136
  Case Report
  EARLY TREATMENT OF EXTRAGONADAL NON-SEMINAL GERM CELL TUMOR WITH HIGH-DOSES CHEMOTHERAPY SUPPORT WITH AUTOLOGOUS HEMATOPOIETIC PROGENITOR CELL TRANSPLANTATION
Slobodan MARJANOVIC, Bela BALINT, Dragana STAMATOVIC, Slobodan OBRADOVIC
  DOI:
  Abstract:
  The majority of patients with disseminated germ cell tumor (GCT) can be cured using contemporary chemotherapy protocols, however, one fourth of patients still died from the disease. In the last few years, in this group of patients, great improvement has been made by high-doses chemotherapy (HDC) regimens supported with autologous hematopoietic progenitor cell transplantation (HPCT). Long term disease free survival in the resistant patients were achieved in 15-20% of them in the early phase of treatment. In the patient with extragonadal, retroperitoneal, non-seminal GCT, after three cycles of chemotherapy (BEVIP protocol) we performed the harvest of peripheral blood HPC, mobilized by high doses Cyclophosfamide and G-CSF. Blood processing volume during apheresis was 22.6 1, end volume of collected HPC was 700 ml, number of total nucleated cells was 4.0x10exp8/kg bm and 12.4x10exp6/kg bm was CD 34+cells. Procedure of programming cryopreservation was performed by our original protocol. Conditioning regimen was CVP protocol. Hematological recovery support by G-CSF (N>0.5x10exp9/1, and P1>50x10exp9/1) was observed on the 12th and 15th day after HPC infusion. Post-transplantatin period was complicated with mild gastrointestinal and hematological toxicity.
  Key words: HIGH-DOSES CHEMOTHERAPY (HDC); AUTOLOGOUS HEMATOPOIETIC PROGENITOR CELL TRANSPLANTATION; EXTRAGONADAL CELL TUMOR
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520