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Year:
1999
| Volume: 7
| Issue: 1
| Pages: 27-28
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Short Report |
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UV VIS SPECTROSCOPIC INVESTIGATIONS OF PLEURAL EFFUSIONS: A POSSIBLE SCREENING DIAGNOSTIC METHOD FOR DIFFERENTIATION OF MALIGNANT FROM NON-MALIGNANT EFFUSIONS
Milka AVRAMOV-IVIC, Jelena ZDRAVKOVIC, Dragan VUKOVIC, Ubavka MIOC, Gordana BOGDANOVIC |
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DOI:
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Abstract: |
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Many diagnostic methods have certain advantages but also a certain degree of invasiveness. Therefore, to establish the final diagnosis, one has to chose between additional diagnostic techniques which are sometimes more or less invasive. UV-VIS spectroscopy is helpful as one of non-invasive and no time-consuming diagnostic method in investigations of pleural effusions.
Typical spectrum was obtained by analysis of the pleural liquid of patients with primary lung carcinoma. This disease was later confirmed by positive clinical, radiological, cytological and hystopathological methods. UV-VIS spectroscopy takes only a few minutes for diagnosis. In 30 out of 35 investigated patients with malignant diseases the obtained spectra were of the same type. We have obtained typical spectra for non-malignant diseases, as well. Our diagnosis was confirmed in 19 cases out of 24 investigated non-malignant patients. In cases of tuberculosis our diagnosis was verified 100%. By UV-VIS spectroscopy we can differentiate malignant and non-malignant diseases with probability of 80% to 85%, immediately after the extraction of pleural effusion. This method can serve as a fast screening non-invasive diagnostic method to differentiate malignant from non-malignant effusions. These preliminary results imply the importance of further investigations that have already been in progress. |
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Key words:
UV-VIS Spectroscopy; Pleural effusions; Malignant and non-malignant diseases; Diagnosis |
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