Founded in 1993
  Year: 2000 | Volume: 8 | Issue: 2 | Pages: 47-50
  Original Article
  FRACTAL DIMENSION OF HEPATOCYTES` NUCLEI IN NORMAL LIVER VS HEPATOCELLULAR CARCINOMA (HCC) IN HUMAN SUBJECTS - PRELIMINARY RESULTS
Aleksandar S. KERENJI, Zoran L. BOZOVIC, Milos M. TASIC, Zoran M. BUDIMLIJA, Istvan A. KLEM, Agneza F. POLZOVIC
  DOI:
  Abstract:
  Background: With the aim of determining the fractal dimension, as an expression of quantitative measure of nuclear shape, in normal and malignant hepatocytes, the box-counting method was performed, followed by linear approximation of necessary numeric values by first degree polynoma.
Materials and Methods: A total of 308 human hepatocyte's nuclei on digitized microscopic images of histological sections (119 normal and 189 hepatocellular carcinoma nuclei) were submitted to fractal analysis, using haematoxylin-eosin stained liver biopsy specimen.
Results: The obtained mean fractal dimension for nuclei of normal hepatocytes was 1.05210.16 versus nuclei of malignant hepatocytes, where was 1.152990.126.
Conclusion: The average values of the nuclear fractal dimensions presented, among normal and malignant hepatocytes are statistically significantly different(p<0.0039).
  Key words: Hepatocellular carcinoma; Nucleus; Fractal analysis; Mathematical model; Humans
  Read full text in PDF [Full Text]
Next article

Previous article

Table of contents

Browse all Volumes

Search all Volumes
By keywords
By authors

  Search AoO for:
 

  Related articles in AoO:
 
About Journal | Editorial Board | Editorial Policy | Instructions for Authors | Open Access | Advertising | Payed issues | Article Submission Charge | Contact
Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520