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Year:
2001
| Volume: 9
| Issue: 1
| Pages: 13-16
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Actual Problem |
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OVARIAN CANCER STAGE III/IV: POOR PROGNOSTIC FACTORS
Aljosa MANDIC, Marija TESIC, Tamara VUJKOV, Nikola NOVTA, Jelka RAJOVIC |
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DOI:
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Abstract: |
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Ovarian cancer accounts for 32% of all gynecologic malignancies but causes 55% of all gynecologic cancer deaths, because some two-thirds of cases are detected in advanced stage. Between 1993 and 1995 we operated 63 patients with ovarian cancer, FIGO stages III /IV, in the Institute of Oncology Sremska Kamenica, Novi Sad. On the basis of several diagnostic methods such as ultrasonography, CT and operative findings we performed radical surgery in 24 (38%) patients, palliative surgery in 25 (40%) and exploratory laparotomy in 15 (22%) patients. Forty-five (71%) patients were treated with the first line chemotherapy according to the protocol CP (carboplatin or cisplatil and cyclophosphamide). Twenty (32%) patients were treated with second look operation after VI series of chemotherapy. Pathohistological examination of biopsies and cytologies were negative only in three (15%) patients. From 1993 to 1993, 85% of all patients with ovarian cancer treated in our Institute, were patients with advanced disease stage III/IV. Eighty-four percent of patients had residual of tumor more than 1-2 cm. Pathohistological types, such as cystadenocarcinoma serosum, carcinoma anaplasticum and clear cell carcinoma were detected in 86% of patients. These types of tumors also have poor prognosis. In our study, a three-year survival rate in the group of patients with advanced disease was 27%. The main problems that affect final results of ovarian cancer treatment, are the lack of early detection, histological type of tumor, stage of disease, and residual tumor volume. |
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Key words:
Ovarian Neoplasms; Neoplasm Staging; Prognosis |
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