Founded in 1993
  Year: 2001 | Volume: 9 | Issue: 1 | Pages: 33-38
  Review Article
  PEPTIDE NUCLEIC ACID - SEQUENCE SPECIFIC RECOGNITION IN CANCER DIAGNOSTICS AND GENE THERAPY
Dragana CETOJEVIC-SIMIN, Dimitar JAKIMOV, Jasminka MRDJANOVIC, Visnja BOGDANOVIC, Vesna KOJIC, Ljiljana ANDRIJEVIC, Gordana BOGDANOVIC
  DOI:
  Abstract:
  Cancer is increasingly recognized as a disease of genes and one of the therapeutic challenges in greatest need of breakthrough. When the first reports about antisenses were published, it was clear that an entirely new era of pharmacology was coming. Practical application of gene targeting to gene therapy is, however, restricted by its low efficiency: generally less than one modified cell in 100 000 treated cells. The optimism culminated with a recent achievements on peptide nucleic acids (PNAs), a man made mimic of natural nucleic acids, as one of the most promising new molecules for recognition of nucleic acids. We present data obtained on the PNAs utility in cancer diagnostics and cancer gene therapy.
  Key words: Peptide Nucleic Acids; Gene Therapy; Neoplasms
  Read full text in PDF [Full Text]
Next article

Previous article

Table of contents

Browse all Volumes

Search all Volumes
By keywords
By authors

  Search AoO for:
 

  Related articles in AoO:
 
About Journal | Editorial Board | Editorial Policy | Instructions for Authors | Open Access | Advertising | Payed issues | Article Submission Charge | Contact
Founder and owner: Oncology Institute of Vojvodina, Serbia
Publisher: Oncology Institute of Vojvodina
Co-publisher: Faculty of Medicine, University of Novi Sad
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520