Founded in 1993
  Year: 2001 | Volume: 9 | Issue: 1 | Pages: 33-38
  Review Article
  PEPTIDE NUCLEIC ACID - SEQUENCE SPECIFIC RECOGNITION IN CANCER DIAGNOSTICS AND GENE THERAPY
Dragana CETOJEVIC-SIMIN, Dimitar JAKIMOV, Jasminka MRDJANOVIC, Visnja BOGDANOVIC, Vesna KOJIC, Ljiljana ANDRIJEVIC, Gordana BOGDANOVIC
  DOI:
  Abstract:
  Cancer is increasingly recognized as a disease of genes and one of the therapeutic challenges in greatest need of breakthrough. When the first reports about antisenses were published, it was clear that an entirely new era of pharmacology was coming. Practical application of gene targeting to gene therapy is, however, restricted by its low efficiency: generally less than one modified cell in 100 000 treated cells. The optimism culminated with a recent achievements on peptide nucleic acids (PNAs), a man made mimic of natural nucleic acids, as one of the most promising new molecules for recognition of nucleic acids. We present data obtained on the PNAs utility in cancer diagnostics and cancer gene therapy.
  Key words: Peptide Nucleic Acids; Gene Therapy; Neoplasms
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520