Founded in 1993
  Year: 2001 | Volume: 9 | Issue: 3 | Pages: 151-153
  Original Article
  Background: The purpose of this study was to evaluate the side effects and reac- tions caused by different antiemetics reported by patients who were receiving high emetogenic, cisplatin (CIS) containing and moderately emetogenic, Cyclophosphamide (CY) containing chemotherapy.
Methods: A total of 260 cancer and lymphoma patients were studied. High dose metoclopramide (MCL), ondansetron (OND), granisetron (GRA) and tropisetron (TRO) alone or in combination with corticosteroids were used for the control of emesis. Side effects and reactions were evaluated according to data, reported in "patient diary" on day 1-6.
Results: A total of 11.2% patients, receiving CIS - containing chemotherapy and 8.2% - CY containing chemotherapy reported side effects. The most serious side effect was headache ranged from 11.4% in the OND group to 7.1% in GRA group. The other side effects and reaction were constipation, diarrhea, extrapyramidal reactions.
Conclusion: MCL and setrons, alone or in combination with CS, were well tolerated. The most frequent side effects observed with dose MCL were extrapyramidal reac- tions and with setrons - headache and constipation.
  Key words: Antiemetics+adverse effects; Metoclopramide; Antineoplastic Agents+adverse effects; Serotonin Antagonists
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520