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POSTER
- TOXICITY DIFFERENCE OF TWO 5-FLUOROURACILA BASED CHEMOTHERAPY
REGIMENS USED IN ADJUVANT TREATMENT OF COLORECTAL CANCER
Muzikravić
Lj, Trifunović J, Janković Lj, Kukić B.
Institute
of Oncology Sremska Kamenica, Sremska Kamenica, Serbia
and Montenegro
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ABSTRACT
In
the period 1985-1990, 103 patients radically operated for colorectal
cancer received adjuvant treatment consisted of two different
5-FU based schedules. Ninety-six patients received planned six
cycles, three patients were given at least three cycles of chemotherapy,
and four patients were not evaluable.The first group of 31 patients
was treated with standard Ansfield's protocol with a daily dose
of 12 mg 5-FU per kg, given intravenously during five successive
days, and repeated every month for each of six cycles.The second
group of 68 patients was treated with combined therapy, using
5-FU in the same dosage as mentioned above, with the addition
of one dose of CCNU 120 mg orally or BCNU 100mg intravenously
in each cycle on day 1. The cycles were repeated every six weeks,
because of delayed toxicity of nitrosourea compounds. Side effects
were common and mild, thus our attention was focused to neutropenia
only. WBC count was determined on day 1 and 3 of each cycle.
Tabela 1. Side effects of chemotherapy
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5-FU
schedule
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5-FU
+ Nitrosourea
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No
neutropenia
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19
(61.3%)
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22
(32.3%)
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41
(41.5%)
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With
neutropenia
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12
(38.7%)
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46
(67.6%)
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58
(58.6%)
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I
II
III
IV
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8
3
1
0
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24
17
2
3
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32
20
3
3
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| -
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31
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68
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99
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The
combined therapy doubled the event of neutropenia then monotherapy.
Grade IV neutopenia was registered only in 3 patients receiving
combined therapy. In one patient it appeared after third cycle
of chemotherapy, and in two patients after the fourth cycle. In
all cases the number of white cells recovered spontaneously, but
further treatment was cancelled.
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