9th International Inter University Scientific Meeting
Academy of Studenica
CLINICAL PROBLEMS IN COLORECTAL CANCER &
ARCHEOLOGY AND MEDICINE

Organizer: Institute of Oncology Sremska Kamenica, Serbia and Montenegro
President: Prof.Dr. Vladimir Vit. Baltić Vice-presidents:Prof. Dr Milan Breberina, Prof. Dr. Zoran Krivokapić
ISSN 1450-708

Content
6 /2003
 
COMBINED TREATMENT OF LOCALLY ADVANCED RECTAL CARCINOMA
Breberina M1, Petrović T1, Radovanović Z1, Muzikravić Lj1, Vukadinović I1, Ađić O1, Bokorov B1, Vujošević B1, Kukić B1, Panjković M1, Stojiljković B1, Novak L2, Struharik R2.
1Institute of Oncology Sremska Kamenica, Sremska Kamenica, Serbia and Montenegro
2Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia and Montenegro
 
  ABSTRACT
To check the value of preoperative radiotherapy in the decrease of frequency of local recurrence of locally advanced rectal carcinoma. Between June 2000 and July 2003 in all patients with histologically proven adenocarcinoma of rectum (up to 12 cm from anal verge) contrast magnetic resonance scan of pelvis was done. In the cases of T3/T4 tumors preoperative radiotherapy (two fields technique AP/PA, 50 Gy, daily fraction 2 Gy) was applied. Six weeks following the end of radiotherapy new magnetic resonance pelvic scan and surgical procedure with total mesorectal excision was done. Forty-one patients were treated (28 males and 13 females) with median age 63 years (range, 42-77 years). Average distance of the tumor from anal verge was 4.8 cm. Six patients (14.6 %) were still inoperable after radiotherapy (two developed distant metastases and in four cases tumor locally progressed). In 35 patients (85.4%) radical operation has been performed (18 low anterior resections and 17 amputations of rectum). Median time of follow up was 19 months and in four cases (11.4%) local recurrence developed 8 to 27 months after Miles operation in all cases. preoperative radiotherapy combined with radical surgery for locally advanced rectal tumors provides high grade of operability.
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  Keywords: Locally advanced rectal cancer, Radiotherapy, Surgery  
© Academy of Studenica, 2003