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10th
International Inter University Scientific Meeting
Academy of Studenica
PERSPECTIVES
IN MELANOMA MANAGEMENT
& NANOTECHNOLOGY IN BIOMEDICINE
Organizers:
Institute of Oncology
Sremska Kamenica; Union of Cancer Prevention
Societies of Vojvodina, Novi Sad; Clinic of Oncology, Nis; Institute
for Oncology and Radiology of Serbia, Belgrade Center for Bioengineering,
Faculty of Mechanical Engineering, University of Belgrade
President:
Vladimir Baltic Vice-presidents: Zlata
Janjic, Radan Dzodic, Borislava Nikolin; Djuro Koruga
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MICROTUBULES
NANOSYSTEM CONTROL
Ratkaj
Ž, Koruga Ð.
Molecular
Machine Research Centar, Faculty of Mecahnical Engineering, Belgrade,
Serbia and Montenegro
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ABSTRACT
In
this paper we explain microtubule process of formation and tubulin
subunits packing from nanosystem control process point of view.
Microtubules are biological structures constitued from two proteins,
alfa and beta tubulin. Those two protein subunits form a dimer,
which in process of self-assembly create spiral and hollow structure.
There are several patterns of creation, and witch pattern will be
formed depends from many aspects. There are several theories about
microtubules pattern creation, but, one thing is the same. Between
any two dimers in one microtubule, there are the same connection
links. Those connections are constituted as ion-ion, ion-dipole
and dipole-dipole connections between aminoacids. Interactions between
two dimers are weak and highly sensitive on changes from enviroment,
mainly force field fluctuations. Here, we are proposing a model
of microtubule packing based on oscilatory characheristics of aminoacids
involved in dimer-dimer side connections. This approach of microtubule
parking may explain taxol-microtubule interaction. |
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Keywords:
tubuline dimer, microtubule, nanosystem control, taxol |
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