|
|
10th
International Inter University Scientific Meeting
Academy of Studenica
PERSPECTIVES
IN MELANOMA MANAGEMENT
& NANOTECHNOLOGY IN BIOMEDICINE
Organizers:
Institute of Oncology
Sremska Kamenica; Union of Cancer Prevention
Societies of Vojvodina, Novi Sad; Clinic of Oncology, Nis; Institute
for Oncology and Radiology of Serbia, Belgrade Center for Bioengineering,
Faculty of Mechanical Engineering, University of Belgrade
President:
Vladimir Baltic Vice-presidents: Zlata
Janjic, Radan Dzodic, Borislava Nikolin; Djuro Koruga
|
|
|
| |
MOLECULAR
IMAGING IN MALIGNANT TUMORS
Prvuloviæ M.
Institute
of Oncology Sremska Kamenica, Diagnostic imaging center, Sremska
Kamenica, Serbia and Montenegro
|
|
| |
ABSTRACT
Molecular
imaging is a technique that uses molecules or generates signals
from molecules to image the structure and function of molecular
systems.Molecular imaging helps visualize the cellular and/or molecular
process in living tissues.Advances in molecular medicine are associated
with new technology and range from various biotechnologies to more
recent nanotechnologies which are examining how biological systems
assemble molecular motors and levers, as well as comunicate ,compute
and store information.Positron emission tomography (PET) use positron
- labeled molecules to image processes such as metabolism , cell
comunication , and gene expression.Single photon emission computed
tomography (SPECT) employ molecules labeled with single-photon emitters.
Optical imaging system use fluorescence or bioluminiscence to image
gene expression in cells. Structural imaging system have been fused
with molecular imaging technologies ,and such mergers include PET/CT,
SPECT/CT, optical fluorescence imaging, magnetic resonance imaging
(MRI), functional MRI , and magnetic resonance spectroscopy (MRS)
using molecular imaging probes. The endogenous reporters exploit
the inherent MRI ability of the gene product to enhance MR signal
within cells.Tyrosinase expression increased a melanin production
, and melanin has a high MR metal (iron) binding capacity , resulting
in high MR signal intensity.Somatostatin receptor subtype II is
anoter reporter gene and through the use I-123 or Tc-99m - labeled
octreotide is positive neuroendocrine and lung tumors can be demonstrated.NIS
(N15 -, a sodium iodide symporter) is an integral protein of basolateral
membrane of thyroid follicular cells.In follicular carcinoma NIS
has been positive in only a few tumor cells, and no NIS protein
expression has been detected in anaplastic carcinoma.NIS gene can
be transfected to specific cancer cells, and the effect of therapeutic
regimens can be easilly monitored by a gama camera using radioiodine
or Tc-pertechentate.One of the goals in molecular imaging research
is the development of universal imaging genes. |
-
|
|
