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10th
International Inter University Scientific Meeting
Academy of Studenica
PERSPECTIVES
IN MELANOMA MANAGEMENT
& NANOTECHNOLOGY IN BIOMEDICINE
Organizers:
Institute of Oncology
Sremska Kamenica; Union of Cancer Prevention
Societies of Vojvodina, Novi Sad; Clinic of Oncology, Nis; Institute
for Oncology and Radiology of Serbia, Belgrade Center for Bioengineering,
Faculty of Mechanical Engineering, University of Belgrade
President:
Vladimir Baltic Vice-presidents: Zlata
Janjic, Radan Dzodic, Borislava Nikolin; Djuro Koruga
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IMAGING
CHARACTERISTICS OF THE MELANOMA OF THE BRAIN, ORBIT AND PARANASAL
SINUSES AND DIFFERENTIAL DIAGNOSIS
Kozić D, Petrović B, *Boškov N,
**Đurić P.
Institute
of Oncology Sremska Kamenica, Diagnostic imaging center, Sremska
Kamenica, Serbia and Montenegro
* General Hospital "Đorđe Joanović", Zrenjanin, Serbia and Montenegro
** Institute of Mother and Child, Belgrade, Serbia
and Montenegro
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ABSTRACT
The
aim of the study is to show imaging characteristics of the brain,
orbit and paranasal sinuses affection with melanoma. Melanoma is
associated with hemorragic metastatic disease of the brain. However
even in the absence of hemorrhage melanoma often presents with T1-shortening
and mild T2-shortening. This paramagnetic effect is observed, most
likely due to presence of melanin molecule with its unpaired electrons.
Ferric iron also, bound to melanin, may contribute to its effect.
Amelanotic metastases of melanoma are not associated with aforementioned
effect. Mealnomas are third most common cause of cerebral metastases,
after carcinoma of the breast and lung. Differential diagnosis includes
hemorrhagic metastatic disease of other etiology (choriocarcinoma,
hypernephroma, bronchogenic carcinoma and occasionaly breast carcinoma).
Ocular melanoma arises from the uveal tract. It is the most common
intraocular malignancy in adults. The tumor is hyperintense on T1W
and PDW images, most likely due to presence of stable free radicals
in melanin. Differential diagnosis includes choroidal detachment,
choroidal hemangioma and choroidal metastases from mucine-producing
adenocarcinomas.
Sinonasal melanocytes occur predominantly in the epithelium and
stroma of the septum and inferior and middle turrbinates. Despite
the lack of pigmentation they can give rise to melanomas. Compared
to brain and ocular affection, sinonasal melanomas do not show quite
specific imaging findings. |
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Keywords:
Melanoma, Brain, Orbit, Paranasal sinuses, MRI |
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