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Year:
2013
| Volume: 21
| Issue: 3-4
| Pages: 118-124
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Review Article |
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INSIGHTS OF POTENTIAL G-QUADRUPLEX SEQUENCES IN TELOMERES AND PROTO-ONCOGENES
Rajendra N. Bhadane, Rupali R. Bhadane, Dhananjay B. Meshram |
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DOI:
https://doi.org/10.2298/AOO1304118B
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Abstract: |
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Guanine rich sequences have the ability to fold into stable 4 stranded structures called G-quadruplex under physiological
concentrations of Na+ or K+. G-quadruplexes are found in telomeres, being stable structures under the control of
telomerase binding proteins. They are also identified throughout the genome and are enriched in promoter regions
of protein coding genes, upstream and downstream of the transcription initiation sites. A number of these promoter
quadruplexes have been investigated for several proto-oncogenes. The formation of these quadruplexes can lead to
chemical intervention of gene expression using a G-quadruplex binding ligand. We review location, configuration, and
stabilization of these quadruplexes in some of the important promoters with regards to their potential as anticancer
target. |
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Key words:
G-Quadruplexes; Telomerase; Guanine; Telomere; Proto-Oncogenes |
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