Founded in 1993
  Year: 2013 | Volume: 21 | Issue: 3-4 | Pages: 118-124
  Review Article
  INSIGHTS OF POTENTIAL G-QUADRUPLEX SEQUENCES IN TELOMERES AND PROTO-ONCOGENES
Rajendra N. Bhadane, Rupali R. Bhadane, Dhananjay B. Meshram
  DOI: https://doi.org/10.2298/AOO1304118B
  Abstract:
  Guanine rich sequences have the ability to fold into stable 4 stranded structures called G-quadruplex under physiological concentrations of Na+ or K+. G-quadruplexes are found in telomeres, being stable structures under the control of telomerase binding proteins. They are also identified throughout the genome and are enriched in promoter regions of protein coding genes, upstream and downstream of the transcription initiation sites. A number of these promoter quadruplexes have been investigated for several proto-oncogenes. The formation of these quadruplexes can lead to chemical intervention of gene expression using a G-quadruplex binding ligand. We review location, configuration, and stabilization of these quadruplexes in some of the important promoters with regards to their potential as anticancer target.
  Key words: G-Quadruplexes; Telomerase; Guanine; Telomere; Proto-Oncogenes
  Read full text in PDF [Full Text]
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520