Founded in 1993
  Year: 1997 | Volume: 5 | Issue: 4 | Pages: 183-185
  Original Article
  KINETICS OF THE REACTIONS BETWEEN TETRACHLOROPLATINATE(II) WITH GLUTATHIONE AND THIOGLYCOLIC ACID. TOXIC SIDE EFFECTS OF PLATINUM ANTITUMOR COMPLEXES
Zivadin D. BUGARCIC, Zorica M. BUGARCIC, Milan JOKSOVIC, Vukadin LEOVAC, Vladimir BALTIC
  DOI:
  Abstract:
  Background: Interactions between platinum complexes and sulphur-bonding ligands are very important from biological and medicine point of view.
Methods: The reaction between tetrachloroplatinate(II) and sulphur-bonding ligands, glutathione and thioglycolic acid, has been studied by conventional spectrophotomerty in an aqueous 0.10 M hydrochloric acid as an ionic medium.
Results: The following values of the second-order rate constants, k2, were obtained at 25oC: (0.115 ± 0.03) M-1s-1, for glutathione and (0.624 ± 0.04) M-1s-1, for thioglycolic acid. The temperature dependence of the rate constants yealds acitivation parameters: DH­ = 38 ± 7 kJ mol-1; DS­ = - 125 ± 8 J K-1 mol-1, for glutathione and DH­ = 31 ± 2 kJ mol-1; DS­ = - 133 ± 7 J K-1 mol-1, for thioglycolic acid. The negative values of the entropies of activation are consistent with an associative mode of activation.
Conclusion: Nephrotoxicity is the result of inactivation of certain enzymes due to the binding of platinum to the sulphydryl groups of cysteine residues. In principle all sulphur-containing biomolecules, such as glutathione, methionine or cysteine could inactivate platinum complexes.
  Key words: Platinum(II); Complex; Thiol group; Glutathion; Thoglycolic acid; Mechanism
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Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520