Founded in 1993
  Year: 1999 | Volume: 7 | Issue: 1 | Pages: 19-22
  Review Article
  SEX HORMONE BINDING GLOBULIN OF THE PLASMA: TOWARDS UNDERSTANDING OF A NEW REGULATORY SYSTEM IN STEROID HORMONE ACTION
Demetrios KOURETAS
  DOI:
  Abstract:
  Sex hormone binding globulin (SHBG) is a protein that circulates in the plasma of many species and binds with high affinity to sex steroids in the human and primates, while it is androgen-binding protein in many animals including sheep, dog, rabbit etc. Its expression is regulated by many hormones and recent evidence has shown that steroids regulate SHBG expression in a species-specific manner. Studies from our laboratory have shown that estrogen binds to SHBG in a non-linear fashion emphasizing the importance of evaluation of SHBG levels in various conditions. The cell membrane SHBG receptor presence in various steroid dependent tissues revealed that SHBG may play an important role in cellular proliferation in those tissues. The present study discusses the recent theories and findings regarding the biological role of SHBG.
  Key words: Sex-steroid; Binding protein; Cancer; Sex hormone binding globulin
  Read full text in PDF [Full Text]
Next article

Previous article

Table of contents

Browse all Volumes

Search all Volumes
By keywords
By authors

  Search AoO for:
 

  Related articles in AoO:
 
About Journal | Editorial Board | Editorial Policy | Instructions for Authors | Open Access | Advertising | Payed issues | Article Submission Charge | Contact
Founder, owner and publisher: Oncology Institute of Vojvodina, Serbia
Online since 1997 (Abstracts only); 2000 (Abstracts and Full text)
ISSN: 0354-7310 eISSN: 1450-9520